The anticonvulsive effect of Diamox was observed on 35 epileptic patients consisted of 18 old ones and 17 fresh ones, from May, 1965 to Sep, 1965, at the Neuropsychiatric Department of Seoul National University Hospital and The 3rd Army Hospital. Among 35 epileptics 9 cases were symptomatic, others idiopathic and in the age of the initial onset 20 cases were from 10 to 19 years old of patient’s age 9 cases from 20 to 29, 3 cases from 30 to 39, 3 case over 40. 29 cases of them were grandmal and other mixed in clinical type.
The doses of medication was 1-2gm/day without any other anticonvulsants, during two months over.
We devided the effectiveness into four groups, Good (80-100% improvement), Fair
(50-80% improvement), Poor (0-50% improvement), Wore (increased in frequency).
RESULTS:
1) We could observe the good response in 57.1% of patients. The more fresh revealed the better result. (TableⅠ)
2) No distinction between the idiopathic and the symptomatic could be found in
response. (TableⅢ)
3) The case of the more frequent attack revealed the better response. (TableⅣ)
4) The side effects could be found in 88.3% of patients. Among them, paresthesia was most predominant symptom. (Table Ⅴ) No severe side effect was observed in all cases. We could control them with decrease of dosage or without any mangement,
5) Some problems remain:
a) The clinical type and the degree of response.
b) The evaluation of the child epilepsy.
c) EEG pattern and degree of response.
d) The biochemical study on the mechanism of action.
We should like to perform above problems at another chance.
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